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POTS in Adults

Research Articles

These articles appear in peer reviewed, scientific journals and are written by those active in researching POTS and other forms of dysautonomia.  When reading journal articles, it can be helpful to focus mainly on the abstract, introduction/background, and discussion section of the paper to get the main idea of the paper.

Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance. 2020. Canadian Journal of Cardiology. Read Article

Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature. 2020. Read Article

Infectious Mononucleosis Complicated by Peritonsillar Abscess and Postural Orthostatic Tachycardia Syndrome: A Case Report. 2020. Sage Journals. Open Medical Case Reports. Read Article

Transient Orthostatic Hypertension During Head-Up Tilt Test in Young Adults: A Phenotype of Blood Pressure Variability. 2020. Journal of Clinical Neurophysiology. Read Article

Prevalence of Orthostatic Hypotension and the Distribution of Pressure Variation in the Longitudinal Study of Adult Health. 2020. Arquivos Brasileiros de Cardiologia. Read Article

Orthostasis. 2020. StatPearls. Read Article

Human Papillomavirus (HPV) Vaccine and Autonomic Disorders: A Position Statement from the American Autonomic Society. 2020. Autonomic Neuroscience. Read Article

Suicide is a Concern for the Chronic Invisible Illness Community. 2020. Journal of Health Science and Education. Read Article

Parent-Child Dyadic Experiences Living with Postural Orthostatic Tachycardia Syndrome (POTS) during Emergent Adulthood. 2020. Read Article

ST-Segment Changes During Tilt-Table Testing in Postural Tachycardia Syndrome: Are They Relevant? 2020. Clinical Autonomic Research. Read Article

Postural Orthostatic Tachycardia Syndrome. 2020. Texas Heart Institute Journal. Read Article 

Increased Prevalence of Autonomic Dysfunction due to Postural Orthostatic Tachycardia Syndrome in Patients with Eosinophilic Gastrointestinal Disorders. 2019. Journal of Gastrointestinal and Liver Diseases 28. Read Article 

The POTS (Postural Tachycardia Syndrome) Epidemic: Hydration and Nutrition Issues. 2019. Nutrition Issues in Gastroenterology. Read Article 

Evaluating and Managing Postural Tachycardia Syndrome. 2019. Cleveland Clinic Journal of Medicine. Read Article 

Human Leukocyte Antigen Associations in Postural Tachycardia Syndrome. 2019. Annals of Clinical and Translational Neurology. Read Article 

Diagnosing and Caring for Patients with Postural Orthostatic Tachycardia Syndrome in Primary Care. 2019. Journal of Health Science and Education. Read Article

Hop to It: The First Animal Model of Autoimmune Postural Orthostatic Tachycardia Syndrome. 2019. Journal of the American Heart Association. Read Article 

Multiple Anesthetic and Obstetric Challenges in a Laboring Patient with Postural Orthostatic Tachycardia Syndrome (POTS) : Acquired Hemophilia and a Rare Seizure Disorder. 2019. Acta Anæsthesiologica Belgica. Read Article 

Utility of Diagnostic Studies for Upper Gastrointestinal Symptoms in Children with Orthostatic Intolerance. 2019. The Journal of Pediatrics. Read Article 

Vitamin D Status Is Not Associated With Orthostatic Hypotension in Older Adults. 2019. Hypertension. Read Article 

PURLs: Best timing for measuring orthostatic vital signs? 2019. The Journal of Family Practice. Read Article 

Tilt Table. 2019. StatPearls. Read Article 

Postural tachycardia syndrome – Diagnosis, physiology, and prognosis. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Low Sensitivity of Abbreviated Tilt Table Testing for Diagnosing Postural Tachycardia Syndrome in Adults With ME/CFS. 2018. Frontiers in Pediatrics. Read Article

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management. 2018.  Journal of Internal Medicine.  Read Article

Clinical symptoms and results of autonomic function testing overlap in spontaneous intracranial hypotension and postural tachycardia syndrome: A retrospective study. 2018. Cephalalgia Reports.  Read Article

Postural Orthostatic Tachycardia Syndrome and Its Unusual Presenting Complaints in Women: A Literature Minireview. 2018. Cureus.  Read Article

Postural tachycardia syndrome (pots) and the GI tract: a primer for the gastroenterologist. 2018. American Journal of Gastroenterology.  Read Article

Postural Hyperventilation as a Cause of Postural Tachycardia Syndrome: Increased Systemic Vascular Resistance and Decreased Cardiac Output When Upright in All Postural Tachycardia Syndrome Variants. 2018. Journal of the American Heart Association.  Read Article

Comparison of Heart Rate Variability Parameters to the Autonomic Reflex Screen in Postural Orthostatic Tachycardia Syndrome and Neurogenic Orthostatic Hypotension. 2018. Journal of Clinical Neurophysiology.  Read Article

Evaluation of postural tachycardia syndrome (POTS). 2018. Autonomic Neuroscience: Basic and Clinical. Read Article

The gastrointestinal symptoms present in patients with postural tachycardia syndrome: A review of the literature and overview of treatment. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Passive standing tests for the office diagnosis of postural tachycardia syndrome: New methodological considerations. 2018. Fatigue: Biomedicine, Health & Behavior.  Read Article

From Postural Orthostatic Tachycardia Syndrome to Radiologically Isolated Syndrome. 2018. Case Reports in Neurological Medicine.  Read Article

Clinical symptoms and results of autonomic function testing overlap in spontaneous intracranial hypotension and postural tachycardia syndrome: A retrospective study. 2018. Cephalagia Reports.  Read Article

Activity and Exercise Intolerance After Concussion: Identification and Management of Postural Orthostatic Tachycardia Syndrome. 2018.   Journal of Neurologic Physical Therapy.  Read Article

Sleep disorders in patients with postural tachycardia syndrome: A review of the literature and guide for clinicians. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Surgical and dental considerations in patients with postural tachycardia syndrome. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Moving from the present to the future of Postural Tachycardia Syndrome–What we need. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Postural Orthostatic Tachycardia Syndrome during pregnancy: A systematic review of the literature. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

The patient perspective: What postural orthostatic tachycardia syndrome patients want physicians to know. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Hypocapnic cerebral hypoperfusion: A biomarker of orthostatic intolerance. 2018. Plos One.  Read Article

Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome. 2018. Journal of Innovative Optical Health Sciences.  Read Article

Successful treatment of postural orthostatic  tachycardia  and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment. 2018. BMJ Case Reports.  Read Article

Emotional orienting during interoceptive threat in orthostatic intolerance: Dysautonomic contributions to psychological symptomatology in the postural tachycardia syndrome and vasovagal syncope. 2018. ELSEVIER.  Read Article

Gastrointestinal Symptoms in Postural Tachycardia Syndrome: A Systematic Review. 2018. Clinical Autonomic Research.  Read Article

Postural Tachycardia Syndrome and Vasovagal Syncope: A Hidden Case of Obstructive Cardiomyopathy without Severe Septal Hypertrophy. 2018. Case Reports in Cardiology.  Read Article

Postural Tachycardia Syndrome: Current Perspectives. 2018. Vascular Health and Risk Management.  Read Article

Cognitive and Psychological Issues in Postural Tachycardia Syndrome. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

 Managing Fatigue in Postural Tachycardia Syndrome (PoTS): The Newcastle Approach. 2018. Autonomic Neuroscience: Basic and Clinical.  Read Article

Postural Orthostatic Tachycardia Syndrome (POTS) in Denmark: Increasingly recognized or new epidemic? 2018. ELSEVIER.  Read Article

 Orthostatic Intolerance. 2018. Evaluation and Management of Autonomic Disorders.  Read Article

Sleep Disturbance Linked to Suicidal Ideation in Postural Orthostatic Tachycardia Syndrome.  2017. Science and Nature of Sleep.  Read Article

Health-Related Quality of Life and Suicide Risk in Postural Tachycardia Syndrome. 2017. Clinical Autonomic Research. Read Article

An assessment of fatigue in patients with postural orthostatic tachycardia syndrome. 2017. Journal of Health Psychology.  Read Article

Postural tachycardia syndrome and suicide: what we don’t know. 2017. Clinical Autonomic Research. Read Article

Effects of intermittent intravenous saline infusions in patients with medication—refractory postural tachycardia syndrome. 2017. Journal of Interventional Cardiac Electrophysiology. Read Article

Is postural tachycardia syndrome in the head or in the heart? And other updates on recent autonomic research. 2017. Clinical Autonomic Research. Read Article

Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome. 2017. Neuroscience and Biobehavioral Reviews. Read Article

Ivabradine in the treatment of postural tachycardia syndrome (POTS), a single center experience. 2017. Pacing and Clinical Electrophysiology.  Read Article

Droxidopa in the Treatment of Postural Orthostatic Tachycardia Syndrome. 2017. American Journal of Therapeutics. Read Article

Mechanisms underlying reflux symptoms and dysphagia in patients with joint hypermobility syndrome, with and without postural tachycardia syndrome. 2017. Neurology and Urodynamics.Read Article

Does Severity of Gastrointestinal Symptoms Correlate with Worsening Autonomic Dysfunction? Use of a Validated Tool for Measuring Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS). 2017. Gastroenterology.  Read Article

Postural Orthostatic Tachycardia Syndrome (POTS): Assess, Diagnose, and Evaluate for POTS Treatment (ADEPT). 2017. Integrative Medicine. Read Article

Cardiovascular testing in patients with postural orthostatic tachycardia syndrome and Ehlers–Danlos syndrome type III. 2017. Clinical Autonomic Research. Read Article

Periodic facial erythema in a patient with postural orthostatic tachycardia syndrome. 2017. Clinical and Experimental Dermatology.  Read Article

Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure? 2017. BioMed Research International.  Read Article

Overactive bladder and autonomic dysfunction: Lower urinary tract symptoms in females with postural tachycardia syndrome. 2016. Neurology and Urodynamics. Read Article

Objective Sleep Assessments in Patients with Postural Tachycardia Syndrome using Overnight Polysomnograms. 2016. Journal of Clinical Sleep Medicine.  Read Article

Orthostatic Intolerance Symptoms are Associated with Depression and Diminished Quality of Life in Patients with Postural Tachycardia Syndrome. 2016. Healthy and Quality of Life Outcomes. Read Article

Postural tachycardia in hypermobile Ehlers-Danlos syndrome: A distinct subtype? 2017. Autonomic Neuroscience: Basic and Clinical. Read Article

Droxidopa in the Treatment of Postural Orthostatic Tachycardia Syndrome. 2016. American Journal of Therapeutics.  Read Article

Management of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia and Vasovagal Syncope. 2016. Arrhythmia & Electrophysiology Review.  Read Article

 The Complexity of Diagnosing Postural Orthostatic Tachycardia Syndrome: Influence of the Diurnal Variability. 2016. Journal of the American Society of Hypertension. Read Article

Spontaneous vs Nitroglycerin-Induced Vasovagal Reflex on Head-up Tilt: Are there Neuroendocrine Differences? 2016. Heart Rhythm.  Read Article

Postural Orthostatic Tachycardia Syndrome is associated with Platelet Storage Pool Deficiency. 2016. Medicine. Read Article

Postural Tachycardia Syndrome (POTS) Is Not Caused by Deconditioning. 2016. Pulmonary Circulation.  Read Article

Dermatological Manifestations of Postural Tachycardia Syndrome Are Common and Diverse. 2016. Journal of Clinical Neurology.  Read Article

Sleep disorders in patients with postural orthostatic tachycardia syndrome. 2016. Clinical Autonomic Research.  Read Article

A profile of patients with postural tachycardia syndrome and their experience of healthcare in the UK. 2016. The British Journal of Cardiology.  Read Article

Manifestations of Anxiety Explaining Tachycardia and Hypertension in a Patient with POTS. 2015. Family Medicine and Medical Science Research.  Read Article

A Case Report and Review of Postural Orthostatic Tachycardia Syndrome in Pregnancy. 2015. AJP Reports.  Read Article

Easily Missed: Resistant Postural Orthostatic Tachycardia Syndrome in a Hypermobile Young Man. 2015. Rheumatology.  Read Article

Quantitative Scale for Grading of Cardiovascular Autonomic Reflex Tests and Small Fibers from Skin Biopsies (QASAT). 2015. Journal of Neurological Disorders.  Read Article

Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome. 2015. The Journal of Physiology.  Read Article

Autonomic activity and biomarker behavior in supine position and after passive postural stress in different orthostatic tachycardia syndromes. 2015. Portuguese Journal of Cardiology. Read Article

Reversible postural orthostatic tachycardia syndrome. 2015. World Journal of Clinical Cases.  Read More

Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome. 2015. Neurogastrolenterol Motil.  Read Article

A survey-based analysis of symptoms in patients with postural orthostatic tachycardia syndrome. 2015. Baylor Medical Center Proceedings.  Read More

Manifestations of Anxiety? Explaining Tachycardia and Hypertension in a Patient with POTS. 2015.  Read More

Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndromeprimary skinfibroblasts. 2015. The FASEB Journal.  Read More

2015 Heart Rhythm Society Expert Consensus Statement on the Diagnosis and Treatment of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia, and Vasovagal Syncope. 2015. Heart Rhythm Society.  Read More

A survey-based analysis of symptoms in patients with postural orthostatic tachycardia syndrome. 2015. Baylor University Medical Center Proceedings.  Read Article

Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study. 2015. Frontiers.  Read Article

Clinical classification and neuro-vestibular evaluation in chronic dizziness. 2015. Clinical Neurophysiology.  Read Article

Take a Stand: A neurologic disorder known as POTS causes dizziness and fainting—and frustration, due to lack of awareness and inadequate treatment. 2015. Neurology Now.  Read Article

Autonomic dysfunction in women with polycystic ovary syndrome. 2015. Iran Journal of Reproductive Medicine.  Read Article

A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome. 2014. Clinical Science (London).  Read Article

Postural tachycardia syndrome is associated with significant symptoms and functional impairment predominantly affecting young women: a UK perspective. 2014. British Medical Journal.  Read Article

Acute Hemodynamic Effects of a Selective Serotonin Reuptake Inhibitor in Postural Tachycardia Syndrome: A Randomized, Crossover Trial. 2014. Journal of Psychopharmacology.  Read Article

Postural Tachycardia Syndrome and Inappropriate Sinus Tachycardia: Role of Autonomic Modulation and Sinus Node Automaticity. 2014. Journal of the American Heart Association.  Read Article

Sleep Disturbances and Autonomic Dysfunction in Patients with Postural Orthostatic Tachycardia Syndrome. 2014. Frontiers in Neurology.  Read Article

Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS). 2014. Frontiers in Physiology.  Read Article

Autoimmune Basis for Postural Tachycardia Syndrome. 2014. Journal of the American Heart Association. Read Article

Postural Orthostatic Tachycardia Syndrome: A Dermatologic Perspective and Successful Treatment with Losartan. 2014. The Journal of Clinical and Aesthetic Dermatology.  Read Article

A Tale of Two Syndromes: Lyme Disease Preceding Postural Orthostatic Tachycardia Syndrome. 2014. Annals of Noninvasive Cardiology.  Read Article

Sympathetic dysfunction in vasovagal syncope and the postural orthostatic tachycardia syndrome. 2014. Frontiers in Physiology.  Read Article

Neuronal and hormonal perturbations in postural tachycardia syndrome. 2014. Review Article. Frontiers.   Read Article

Confounders of Vasovagal Syncope: Postural Tachycardia Syndrome. 2013. Cardiology Clinicians.  Read Article

Effects of Norepinephrine Reuptake Inhibition on Postural Tachycardia Syndrome. 2013. Journal of the American Heart Association.  Read Article

Gastric Emptying in Postural Tachycardia Syndrome: A Preliminary Report. 2013. Clinical Autonomic Research.  Read Article

Structural and Functional Small Fiber Abnormalities in the Neuropathic Postural Tachycardia Syndrome. 2013. Plos One.  Read Article

What is brain fog? An evaluation of the symptom in postural tachycardia syndrome. 2013. Clinician Autonomic Research.  Read Article

Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes. 2012. Clinical Science (London).  Read Article

Diagnosis and management of postural orthostatic tachycardia syndrome: A brief review. 2012. Journal of Geriatric Cardiology.  Read Article

Postural Tachycardia Syndrome: A Heterogeneous and Multifactorial Disorder. 2012. Proceedings of Mayo Clinic.  Read Article

Mechanisms of sympathetic regulation in orthostatic intolerance. 2012. Journal of Applied Physiology.  Read Article

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome. 2012. Clinical Science.  Read Article

Sleep Disturbances and Diminished Quality of Life in Postural Tachycardia Syndrome. 2011. Journal of Clinical Sleep Medicine.  Read Article

Postural orthostatic tachycardia syndrome following Lyme disease. 2011. Cardiology Journal.  Read Article

Comparative Clinical Profile of Postural Orthostatic Tachycardia Patients With and Without Joint Hypermobility Syndrome. 2010. Indian Pacing Electrophysiology Journal.  Read Article

Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis. 2010. International Journal of Medical Sciences.  Read Article

Effect of Pregnancy on Postural Tachycardia Syndrome. 2010. Mayo Clinic Proceedings.  Read Article

Menstrual Cycle Affects Renal-Adrenal and Hemodynamic Responses During Prolonged Standing in the Postural Orthostatic Tachycardia Syndrome. 2010. Hypertension.  Read Article

Postural tachycardia syndrome (POTS). 2009. Journal of Cardiovascular Electrophysiology.  Read Article

Defects in Cutaneous Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7) Production in Postural Tachycardia Syndrome. 2009. Hypertension.  Read Article

Postural Tachycardia Syndrome. 2008. Circulation.   Read Article

Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome. 2008. QMJ: An International Journal of Medicine.   Read Article

Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome. 2008. American Journal of Physiology - Heart and Circulatory Physiology.   Read Article

Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome. 2007. American Journal of Physiology - Heart and Circulatory Physiology.  Read Article

The Postural Tachycardia Syndrome (POTS): Pathophysiology, Diagnosis & Management. 2006. Indian Pacing Electrophysiology Journal.   Read Article

Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow. 2006. American Journal of Physiology - Heart and Circulatory Physiology.   Read Article

Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders. 2005. Hypertension.   Read Article

Fludrocortisone Acetate to Treat Neurally Mediated Hypotension in Chronic Fatigue Syndrome: A Randomized Controlled Trial. 2001. The Journal of the American Medical Association.  Read Article

The Neuropathic Postural Tachycardia Syndrome. 2000. New England Journal of Medicine.  Read Article

Chronic Orthostatic Intolerance: A Disorder With Discordant Cardiac and Vascular Sympathetic Control. 1998. Circulation.  Read Article